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                                                                                                                            孙斐

                                                                                                                            发布日期:2018-02-19 09:38 发布作者:生殖医学研究院 阅读次数: 字号:[ ]


                                                                                                                            个人介绍: 孙斐,主任医师、教授、博士生导师。南通大学医学院院长。主持国家杰出青年基金、中科院"百人计划"、国家基金委重点项目,作为项目首席科学家先后主持国家973计划、国家重点研发计划等多项国家科技计划。现担任《Molecular Human Reproduction》编委、《Reproductive Biology and Endocrinology》编委、《Asian Journal of Andrology》编委、《中华男科学杂志》副主编、《生殖医学杂志》编委、中华医学会计划生育学分会委员、男性生育调控学组副组长、中国中西医结合学会男科、妇产科、生殖医学3个专业委员会常委、中国动物学会生殖生物学分会常务理事等。主要从事男性不育的临床和基础研究。工作以来,作为第一或通讯作者共发表Am J HumGenet、Hum Mol Genet等SCI论文50余篇,其中12篇论文分别被当期杂志选作封面。 2011年荣获首届中西医结合优秀青年贡献奖,2012年荣获安徽省青年科技奖,2015年首届妇幼健康科技奖科技成果一等奖。

                                                                                                                            联系方式:邮箱: sunfei@ntu.edu.cn

                                                                                                                            教育经历:

                                                                                                                            1997.09-2000.07复旦大学妇产科学医学博士

                                                                                                                            1994.09-1997.07青岛大学妇产科学医学硕士

                                                                                                                            1989.09-1994.07徐州医科大学临床医学医学学士

                                                                                                                            工作经历:

                                                                                                                            2016.12 - 南通大学医学院院长教授、主任医师

                                                                                                                            2014.11-2016.11上海交通大学医学院附属国际和平妇幼保健院教授、主任医师

                                                                                                                            2006.09-2014.10中国科学技术大学生命科学学院教授

                                                                                                                            2001.02-2001.10阿根廷国立科多巴大学访问学者

                                                                                                                            2000.10-2006.08以色列魏茨曼科学院、加拿大卡尔加里大学博士后

                                                                                                                            研究方向

                                                                                                                            男性不育发生的分子遗传学机制:主要研究非编码RNAs 及其它表观遗传因素调控精子发生、男性不育和生殖细胞肿瘤发生的分子机制,寻找治疗该类疾病的分子靶点。

                                                                                                                            配子形成过程中减数分裂机制及调控:主要研究配子形成过程中减数分裂同源染色体不分离(nondisjunction)的机制及调控 (如年龄、环境因素),及DNA错配修复蛋白在配子发生中的作用。

                                                                                                                            代表性论文

                                                                                                                            1.LianJ, Yin YM, Oliver-Bonet M, Liehr T, Ko E, Turek P, Sun F, Martin RH. Variation in crossoverinterference levels on individual chromosomes from human males. Hum Mol Genet, 2008, 17(17):2583-2594. Selected for cover illustration.

                                                                                                                            2.Lian J, Zhang XS, Tian H, Liang N, Wang Y,Liang CZ, Li X, Sun F. Altered microRNA expression in patientswith non-obstructive azoospermia.Reprod Biol Endocrinol, 2009, 7:13.

                                                                                                                            3.Yao GD, Yin MM,Lian J, Tian H,Liu L, Li X, Sun F.MicroRNA-224 is involved intransforming growth factor-β-mediated mouse granulosa cel1 proliferation andgranulosa cell function by targeting Smad4. Mol Endocrinol,2010,24(3): 540-551.

                                                                                                                            4.Lian J, Tian H, LiuL, Zhang XS, Li WQ, Deng YM,Yao GD, Yin MM, Sun F.Down-regulation of microRNA-383 is associated with male infertility andpromotes testicular embryonal carcinoma cell proliferation by targeting IRF1. Cell Death Dis2010,1, e94; doi:10.1038/cddis.2010.70. Highlighted in Cell Death Dis.


                                                                                                                            Article of the month

                                                                                                                            Downregulation of microRNA-383 isassociated with male infertility and promotes testicular embryonal carcinomacell proliferation by targeting IRF1
                                                                                                                            A recent study looks at the underlying mechanisms of miR-383 in maturation arrest, providing newideas for treatment and investigating the connection between male infertilityand testicular germ cell tumors.

                                                                                                                            5.Liang N, Xu YL, Yin YM, Yao GD, Tian H, WangGS, Lian J, Wang Y, and Sun F.Steroidogenic Factor-1 Is Required for TGF-β3-Mediated 17β-Estradiol Synthesisin Mouse Ovarian Granulosa Cells. Endocrinology2011 Aug;152(8):3213-25.Editor's Choice

                                                                                                                            6.YinM, Lü M, Yao G, Tian H, Lian J, Liu L, Liang M, Wang Y, Sun F. Transactivation of microRNA-383 by Steroidogenic Factor-1Promotes Estradiol Release from Mouse Ovarian Granulosa Cells by TargetingRBMS1.MolEndocrinol. 2012Jul;26(7):1129-43

                                                                                                                            7.Li WQ, Wang F, Liu ZM, Wang YC, Wang J, Sun F. GoldNanoparticles Elevate Plasma Testosterone Levels in Male Mice without AffectingFertility.Small2013,9(9-10):1708-14.

                                                                                                                            8.Liu Z, Li W,Wang F, Sun C, Wang L, Wang J, SunF. Enhancement oflipopolysaccharide-induced nitric oxide and interleukin-6 production byPEGylated gold nanoparticles in RAW264.7 cells. Nanoscale, 2012, 4 (22),7135 – 7142.

                                                                                                                            9.Yin Y, Wang G,Liang N, Zhang H, Liu Z, Li W, SunF. Nuclear export factor 3 is involved inregulating the expression of TGF-β3 in an mRNA export activity-independentmanner in mouse Sertoli cells. Biochem J 2013, 452 (1), 67 – 78.

                                                                                                                            10.Liang,M., Yao, G., Yin, M., Lü, M., Tian, H., Liu, L., Lian, J., Huang, X., Sun F.

                                                                                                                            Transcriptional cooperation between p53and NF-κB p65 regulates microRNA-224 transcription in mouse ovarian granulosacells. Mol Cell Endocrinol 2013, 370 (1-2), 119 – 129.

                                                                                                                            11.Liu L, Lian J,Zhang H, Tian H, Liang M, Yin M, SunF. MicroRNA-302a sensitizes testicularembryonal carcinoma cells to cisplatin-induced cell death.J Cell Physiol. 2013, 228 (12): 2294–2304

                                                                                                                            12.Tian H, Cao YX,Zhang XS, Liao WP, Yi YH, Lian J, Liu L, Huang HL, Liu WJ, Yin MM, Liang M,Shan G, Sun F. The targeting andfunctions of miRNA-383 are mediated by FMRP during spermatogenesis.Cell Death Dis. 2013 May 2;4: e617. doi: 10.1038/cddis.2013.138.

                                                                                                                            13.LiWQ, Sun C, Wang F, Wang YC, Zhai YW, Liang M, Liu WJ, Liu ZM, Wang J, Sun F. Achieving a new controllablemale contraception by photothermal effect of gold nanorods. Nano Lett 2013, 13(6), 2477–2484. Comments on: NatureMatertials 2013,12 (7), 602: Nano contraceptionChemistry World:Will nanorods be the next big male contraceptive idea? Chemistry &Engineering News: Reversible MaleContraception With Gold Nanorods.

                                                                                                                            14.YaoG, Liang M, Liang N, Yin M, Lü M, Lian J, Wang Y, Sun F. MicroRNA-224 is involved in the regulation of mouse cumulusexpansion by targeting Ptx3. Mol Cell Endocrinol 2014, 382 (1), 244-253.

                                                                                                                            15.WangY, Liang N, Yao G, Tian H, Zhai YW,YinYM, Sun F. Knockdown of TrkA incumulus oocyte complexes (COCs) inhibits EGF-induced cumulus expansion bydown-regulation of IL-6. Mol Cell Endocrinol 2014, 382 (2), 804-813.

                                                                                                                            16.HuangH, Tian H, Duan Z, Cao Y, Zhang XS, SunF. microRNA-383 impairs phosphorylation of H2AX by targeting PNUTS andinducing cell cycle arrest in testicular embryonal carcinoma cells. Cell Signal2014, 26(5), 903-911

                                                                                                                            17.LiuW, Wang L, Zhao W, Song G, Xu R, Wang G, Wang F, Li W, Lian J, Tian H, Wang X, Sun F. Phosphorylation of CDK2 atthreonine 160 regulates meiotic pachytene and diplotene progression in mice.Dev Biol 2014, 392(1):108-16.

                                                                                                                            18.WangL, Liu W, Zhao W, Song G, Wang G, Wang X, SunF. Phosphorylation of CDK2 on Threonine 160 Influences Silencing of SexChromosome During Male Meiosis. Biol Reprod 2014, 90 (6) 138, 1-7.

                                                                                                                            19.YinM, Wang X, Yao G, Lü M, Liang M, Sun Y, SunF. Transactivation of MicroRNA-320 by MicroRNA-383 Regulates Granulosa CellFunctions by Targeting E2F1 and SF-1 Proteins. J Biol Chem 2014, 289 (26):18239-18257.

                                                                                                                            20.WangY, Liu W, Du J, Yu Y, Liang N, Liang M, Yao G, Cui S, Huang H, Sun F. NGF promotes mouse granulosacell proliferation by inhibiting ESR2 mediated down-regulation of CDKN1A. MolCell Endocrinol 2015, 406 (5): 68–77

                                                                                                                            21.WangG, Zhang H, Wang L, Wang Y, Huang H, SunF. Ca(2+)/Calmodulin-Dependent Protein Kinase IV Promotes Interplay ofProteins in Chromatoid Body of Male Germ Cells. Sci Rep 2015; 5: 12126. doi:10.1038/srep12126.

                                                                                                                            22.Lü M, Tian H,Cao YX, He X, Chen L, Song X, Ping P, Huang H, Sun F*. Downregulation of miR-320a/383-sponge-like long non-codingRNA NLC1-C (narcolepsy candidate-region 1 genes) is associated with maleinfertility and promotes testicular embryonal carcinoma cell proliferation.Cell Death Dis. 2015, 6: e1960. doi: 10.1038/cddis.2015.267.

                                                                                                                            23.Lu Wang,Yueshuai Guo, Wenjing Liu, Weidong Zhao, Gendi Song, Tao Zhou, Hefeng Huang,Xuejiang Guoand Fei Sun*. Proteomic analysis of pachytene spermatocytes of sterilehybrid male mice. Biol Reprod 2016, 95(3):52, 1–7.

                                                                                                                            24.Wang L, Xu F,Wang G, Wang X, Liang A, Huang H, Sun F.*.C30F12.4 influences oogenesis, fat metabolism, and lifespan in C. elegans.Protein Cell. 2016 Oct;7(10):714-721. Cover art.

                                                                                                                            25.Zhang H, Wang G,Liu L, Liang X, Lin Y, Lin YY, Chou CF, Liu MF, Huang H, Sun F. KH-type splicing regulatory protein is a new component ofChromatoid body. Reproduction. 2017, 154(6): 723-733.

                                                                                                                            26.Zhao W, Li Z,Ping P, Wang G, Yuan X, Sun F. Outerdense fibers stabilize the axoneme to maintain sperm motility. J Cell Mol Med.2017 Nov 23. doi: 10.1111/jcmm.13457.

                                                                                                                            27.Zheng X, Li Z,Wang G, Li Z, Liang A, Wang H, Dai Y, Huang X, Chen X, Ma Y and Sun F.Overexpression of Human-Derived DNMT3A Induced IntergenerationalInheritance of Active DNA Methylation Changes in Rat Sperm. Front Genet 2017.8: 207. doi: 10.3389/fgene.2017.00207

                                                                                                                            专利:

                                                                                                                            1 金纳米棒在雄性避孕中的用途中国2014

                                                                                                                            2 小分子核酸miR-302用于治疗或预防睾丸癌的用途中国2014

                                                                                                                            获奖情况:

                                                                                                                            2011年荣获首届中西医结合优秀青年贡献奖2012年荣获安徽省青年科技奖2015年首届妇幼健康科技奖成果一等奖(排名第二)


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