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张小宁

发布日期:2019-05-09 15:47 发布作者:生殖医学研究院 阅读次数: 字号:[ ]

单位:南通大学医学院(生殖医学研究院)
地址:南通大学科技园
E-mail: 649940132@qq.com

教育经历:
2010.8—2014.12
,兰州大学,动物学,博士
2006.9—2010.7
,兰州大学,生物技术,理学学士

工作经历

2019.5—至今,南通大学医学院(生殖医学研究院),副教授(校聘)

2015.1—2019.4,南昌大学生命科学研究院,助理研究员

研究领域:
精子发生与精子功能调控的lncRNA机制;雌性生殖道因子对成熟精子功能调控的钙信号与表观遗传学机制。
目前研究包括:
1lncRNA及其互作蛋白对精子变形的调控;
2)精浆外泌体和卵泡液外泌体对成熟精子的功能调控;
主持科研项目:
1.
国家自然科学基金(81760283):弱精症相关 lncRNA ASAL1 在人成熟精

子中的功能与机制研究、2018/01-2021/1233 万、在研、主持。

2. 国家自然科学青年基金(31801238):lncSR1 STRBP 调控精子变形中

的作用与机制研究、2019/01-2021/1225 万、在研、主持。

3. 甘肃省环境生物监测与修复重点实验室开放基金项目(GBBL2015002):双酚 A 对精子功能的影响及机制研究、2016/01/01-2018/12/122.0 万元、主持。

4. 2013 年中央高校基本科研业务费优秀研究生创新项目(Lzujbky-2013-241):氯酚类化合物诱导细胞死亡的机制研究、2013/01-2014/122 万元、主持。

文章发表(*通讯作者):
1.Xiaoning Zhang, Peng Zhang, Dandan Song, Suping Xiong, Hongyan Zhang, JianboFu, Fengxin Gao, Houyang Chen, Xuhui Zeng*. Expression profiles and characteristicsof human lncRNA in normal and asthenozoospermia sperm.Biology of Reproduction.2018. (online) (SCI
二区, IF= 3.184)

2. Liping Zheng, Ruichen Luo, TieSu, Liaoliao Hu, Fengxin Gao, Xiaoning Zhang(*). Differentiallyexpressed lncRNAs after the activation of primordial follicles in mouse.Reproductive Sciences. 2018. doi: 10.1177/1933719118805869. (SCI 三区, IF= 2.548)

3. Xiaoning Zhang, FengxinGao, Jianbo Fu, Yuqing WangXuhui Zeng*.Systematic Identification and Characterization of Long Non-coding RNAs in MouseMature Sperm. Plos One. 2017;12(3): e0173402. (SCI 三区, IF= 2.766)

4. Fengxin Gao(#), Peng Zhang(#),Hongyan Zhang, Yunhui Zhang, Yunwen Zhang, Qingyun Hao, Xiaoning Zhang(*).Dysregulation of long noncoding RNAs in mouse testes and spermatozoa afterexposure to cadmium. Biochemical and Biophysical Research Communications. 2017;484(2017):8-14. (SCI 三区, IF= 2.559)

5. Jianbo Fu, Xiaoning Zhang(*), Peng Chen and Yingmei Zhang. Endoplasmicreticulum stress is involvedin 2,4-dichlorophenol-induced hepatotoxicity. The Journal of ToxicologicalSciences. 2016;6:745-756. (SCI 四区, IF= 1.719)6.Xiaoning Zhang, Hui Li, Yongmei Qi, Dejun Huang, Yingmei Zhang.2,4-Dichlorophenol induces global DNA hypermethylation through the increase ofS?adenosylmethionine and the upregulation of DNMTs mRNA in the liver ofgoldfish Carassius auratus. Comparative biochemistry and physiology. Part C.2014;160:54-9. (SCI 二区, IF= 2.426)

7. Xiaoning Zhang, XiaonaZhang, Yongmei Qi, Dejun Huang, Yingmei Zhang. 2,4-Dichlorophenol induces ERstress-mediated apoptosis via eIF2α dephosphorylation in vitro. Environmentaltoxicology. 2016.31(2):245-255. (SCI二区,IF= 2.491)

8. Xiaoning Zhang, XiaonaZhang, Zhidan Niu, Yongmei Qi, Dejun Huang, Yingmei Zhang.2,4,6-Trichlorophenol cytotoxicity involves oxidative stress, endoplasmicreticulum stress and apoptosis. International journal of toxicology.2014;33(6):532-541. (SCI 四区, IF= 1.504)

9. Dejun Huang*, XiaoningZhang, Chen Zhang, Hui Li, Dong Li, Yan Hu, Feng Yang, and Yongmei Qi.2,4-Dichlorophenol Induces DNA Damage through ROS Accumulation and GSHDepletion in Goldfish Carassius auratus. Environ Mol Mutagen. 2018Dec;59(9):798-804. (SCI 二区, IF= 3.254)

10. Yingxia Liu, Wenya Zhang, XiaoningZhang, Yongmei Qi, Dejun Huang, Yingmei Zhang. Arsenic trioxide inhibitsinvasion/migration in SGC-7901 cells by activating the reactive oxygenspecies-dependent cyclooxygenase-2/matrix metalloproteinase-2 pathway.Experimental Biology and Medicine. 2011; 236: 592–597. (SCI 三区, IF= 2.413)

11. Hui Li, Xiaoning Zhang,Qian Qiu, Zhen An, Yongmei Qi, Dejun Huang,Yingmei Zhang. 2,4-Dichlorophenolinduces apoptosis in primary hepatocytes of grass carp (Ctenopharyngodonidella) through mitochondrial pathway. Aquatic Toxicology.2013,140–141:117-122. (SCI 一区, IF= 3.884)

12. Xue Wei, Yongmei Qi, XiaoningZhang, Qian Qiu, Xueyan Gu, Chen Tao, Dejun

Huang, Yingmei Zhang. Cadmiuminduces mitophagy through ROS-mediated PINK1/Parkin pathway in kidney of mice.Toxicology mechanisms and methods. 2014, 23:1-24. (SCI 四区, IF= 1.994)

13. Xue Wei, Yongmei Qi, XiaoningZhang, Xueyan Gu, Hui Cai, Jing Yang, and Yingmei Zhang. ROS act as anupstream signal to mediate Cadmium-induced mitophagy in brain of mouse[J].Neurotoxicology. 2015;46C: 19-24. (SCI 二区,IF= 3.076)

14. Weiwei Li, Xueyan Gu,Xiaoning Zhang, Jinxin Kong, Nan Ding, Yongmei Qi, Yingmei Zhang, JufangWang, Dejun Huang. Cadmium delays non-homologous end joining(NHEJ) repair viainhibition of DNA-PKcs phosphorylation and downregulation of XRCC4 andLigaseIV. Mutation Research. 2015;779:112–123.

(SCI 三区, IF= 2.398)

15. Zhidan Niu, Wenya Zhang,Xueyan Gu, Xiaoning Zhang, Yongmei Qi, Yingmei Zhang. Mitophagy inhibitsproliferation by decreasing cyclooxygenase-2 (COX-2) in arsenictrioxide-treated HepG2 cells. Environmental Toxicology and Pharmacology.2016;45:212-221. (SCI 三区, IF=2.776)

16. 王语晴, 高丰鑫,张小宁(*). 哺乳动物精浆胞外囊泡及各组分的功能. 中国

生物化学与分子生物学报. 2018 ,34( 2) :162-169.

17. 张小宁,邱倩,李慧,黄德军,张迎梅(*). 草鱼细胞内凋亡抑制蛋白多克隆抗体的制备和检测.中国科技论文在线精品论文. 2013,6(17):1651-1656.


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